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The game is played by selecting five moves in a menu before each round. Each move has a different chance of success and do varying amounts of damage. If three attacks in a row are successful, a super move is unlocked.
- Flying Buttress: The Masked Mumbler jumps up and crushes Lee with his butt.
- Rejuvenate: Nazz comes out and kisses The Masked Mumbler, making him heal.
- Trash Can Block: Eddy puts a garbage can over the Masked Mumbler to protect him from Lee's attacks.
- Steamroller: The Masked Mumbler rolls over Lee like a steam roller.
- Monkey Mangler: The Masked Mumbler turns into a monkey and jumps on Lee.
- Pile Driver: The Masked Mumbler goes on his hands with his feet turning into a metal hammer that hit Lee like she is a nail.
- Snake Squeeze Hold: (unlocked after the first level) The Masked Mumbler turns into a snake and squeezes Lee.
- Super Belly Flop: (unlocked after the first level) The Masked Mumbler jumps on Lee with his belly, crushing her.
- Stink Foot Surprise: (unlocked after the second level) The Masked Mumbler takes off his sock and puts his stinky foot in Lee's face.
- The Big Bad Bomb Drop: (unlocked after the second level) The Masked Mumbler turns into a bomb and bombs Lee.
- Pizza Dough: Lee grabs the Masked Mumbler and spins him around while throwing him up in the air.
- Jump Rope: Lee stretches the Masked Mumbler out and plays jump rope with him as the rope.
- Knot: Lee ties the Masked Mumbler into a knot.
- Trash Can Block: Same as Masked Mumbler's move.
- Workout: Lee gets a giant weight and works out, healing herself.
- Noogies: Lee gives the Masked Mumbler a noogie.
Lee's Unlocked Moves
- Plunger: (unlocked after the first level) Lee plunges the Masked Mumbler into the ground.
- Kiss Kiss: (unlocked after the first level) Lee kisses the Masked Mumbler.
- Tornado: (unlocked after the second level) Lee grabs the Masked Mumbler and spins him around like a tornado.
- Accordion: (unlocked after the second level) Lee grabs the Masked Mumbler and plays him like an accordion.
- Edd: Ed and Eddy enter the fight and knock Lee down with their arms.
- Lee: Marie and May approach and stampede Edd.
- The Clash of the Idiot stage was included in M.U.G.E.N but unknown it if has a download link.
- The background music intentionally sounds like the Survivor song Eye of the Tiger.
- This game is based on the wrestling match seen in "Tag Yer Ed".
- The game's title is a reference to the 1981 film Clash of the Titans.
- Marie is slightly off-model.
- Everyone in the show appears in this game (Edd as "The Masked Mumbler", Lee as his opponent, Eddy as Edd's assistant and part of the super move, Ed as part of the super move, Marie as Lee's assistant and part of the super move, May as part of the super move, Nazz as part of Edd's "Rejuvenate" move, and the rest of the kids and Plank as spectators).
- When Lee uses the Trash Can Block, Edd will always attempt to attack using the Flying Buttress. When he uses the Trash Can Block, however, Lee will attempt to attack with Kiss Kiss.