Revolt of the Rotting Brains is a comic that Ed owns. It was only seen in Ed, Edd n Eddy's Big Picture Show. Beyond the information given in the title, not much is revealed about it. It appeared when Ed pulled it out of his jacket to show his friends an ad for the Lemon Brook Gag Factory; as Edd figured out that Eddy's Brother was an inveterate prankster and would therefore probably be located somewhere with a lot of gags. When they got to the factory, however, they found that it was long-since abandoned, with a thick film of dust everywhere. Upon seeing this, Edd looked over the comic and realized that it was over ten years old. Angered by this, Eddy tosses the comic. It is unknown what happened to it afterwards, as Ed chased after it but was never shown finding it again.
- Edd proclaims that the comic is over ten years old when he looks at the copyright date, but the Eds are all implied to be not quite teenagers. As such, this raises the question of how Ed got the comic. It's possible that his parents bought it for him when he was a small child, or that he found it himself.
- Similarly, Ed refers to the comic as a classic.
- The back cover of the comic advertises a weight loss solution. It features an image of a bicycle, along with a before and after silhouette of a person claiming to have lost 61 pounds.