"They Call Him Mr. Ed" is the 9th episode of Season 4 and the 86th episode of Ed, Edd n Eddy. In this episode, Eddy decides to go nowhere but up and as such creates a business known as Ed Co. He then starts convincing people in the Cul-de-Sac to work for his new corporation and go nowhere but up.
For once, Edd is hanging out with Ed without any interference, and naturally he wants to run some tests on Ed to see his aptitude. To this end, he has rigged up a "Maze of Inevitable Despair", and if Ed completes it, he'll be given a full box of Chunky Puffs (part of a complete breakfast). Ed loves Chunky Puffs, so he naturally is raring to go, and when Edd tells him to go through the maze, he quite literally goes through it by simply running through the cardboard walls on a race to the exit, where the cereal is. Once there, he ingests the cereal despite Edd's irritation due to the fact that he went through the maze incorrectly. Suddenly, Eddy arrives, and tells them that he's come up with a great idea: up! Edd is confused, but Ed gets it, and Eddy drags his friends off to his driveway to set up the scam.
Soon enough, the scam is set up, complete with Eddy having a desk with a phone on it. Of course, the purpose is to go up, so Ed is leaping into the air. Unfortunately, he can't stay up, so Eddy turns to Edd, who has constructed an elevator for that express purpose. After seeing it demonstrated, Eddy is suitably impressed and returns to his desk, while Ed decides to continue working on the elevator. When Eddy gets back to work, however, he finds Jonny wants to know what they're doing. As Edd escorts out the boy Eddy terms the "never-ending forehead", he explains that opportunities come up in the blink of an eye at Ed Co., and hands over his card. Jonny is impressed that Edd has a card, and soon informs Nazz and Jimmy as to what is going on.
A few minutes later, business is booming at Ed Co., with six phones now sitting on Eddy's desk, all of them ringing off the hook. Edd soon disturbs the boss, however, when he brings in Nazz, who wants a job. A nervous Eddy hires her on as secretary, and soon enough calls Edd in for another job. Eddy wants a go-getter, an up-and-comer, a maverick to move the plot along, so whom better to ask than (much to Edd's surprise) Jimmy? Eddy has Edd call Jimmy into the office, but this means that Jonny will be up next. Thinking quickly, Edd sticks Jonny in the mailroom, while Eddy hires on Jimmy.
Soon, Jimmy has become the office decorator and has made the office in a veritable paradise. Rolf has taken on a position as well, as security guard, which in his mind has several parallels to being a shepherd, namely that he now guards his own flock of simple-minded creatures. Kevin then arrives, however, and the office is quickly thrown into disarray, as he keeps using the word "down". When Rolf tries to throw him out, a fight breaks out, and all of Jimmy's hard work is wrecked. When Eddy sees that Rolf might be defeated, he comes out and angrily berates Rolf, asking what he pays Rolf for anyway.
Hearing Eddy mention pay, the kids all suddenly realize that they aren't getting paid at all. They angrily ask for an explanation, but the only one that can be offered up by Edd is that the company is a nonprofit, which causes all the kids to angrily leave. Upset about his business going down, Eddy begs Edd for some relief and a way to go up. Edd has no ideas, but he does witness Ed acting strangely, and asks what he's been up to. The Eds gather inside the elevator in a last-ditch effort of maintaining their "upness," and continue through Ed's makeshift extensions all the way to outer space. Shocked, Edd asks if Ed spent his whole day doing this, but Eddy and Ed are too excited to listen and instead clamber upon the crescent moon, sure they've gone as up as possible. Unfortunately, their weight is too much for the moon, and it shakes and comes loose, leaving them hanging precariously over the Earth. Seeing their position, Eddy instantly changes his tune, and his friends follow suit, as now they want to go nowhere but down.
Ed: [blindfolded] "Fe fie fo fum! I smell Chunky Puffs!" [Ed sticks his tongue out.]
Eddy: [to Edd as he's being pestered by Jonny] "Does the never-ending forehead have an appointment?"
Rolf: [sitting in his security cubicle] "Ah, life is good, Victor. The son of a shepherd now protects his own flock of simpleminded creatures." Kevin: [mocking Rolf's outfit] "What's with the 'Car 54' get up, Rolf? Afraid someone might steal your box?"
Rolf: [fighting with Kevin] "May you break out in lather and pass a turnip from your nose!"
Kevin: "Down for the count, dorks!" Jimmy: [as Eddy's business collapses] "My artistic vision sullied! I'm so downhearted!" Nazz: [annoyed] "Downright lame, if you ask me." Rolf: [angry at not being paid] "Downtrodden rabbit radishes! Come, Victor!" Jonny: [obliviously happy] "Hey guys! Did everyone get to see Plank's butt?" Edd: "I'm afraid it's downhill from here, Eddy." Eddy: [about to crack] "Nowhere but up, Double D!"
Eddy: "Ed! What are you up to?" Ed: "Uhh, is that a quiz or something?"
Nazz: [looking at Jonny's picture] "What is this?" Jonny: "Plank photocopied his butt!"
When Ed was sniffing a piece of Chunky Puffs, his tongue was purple, but in the next scene it's light blue (which is Ed's regular tongue color).
Inside the elevator, at first it is brown and blue. However, two more colors appear inside it later on.
When Ed is in the air and says "Whoa!" his mouth doesn't match up with his line.
Ed carrying the large building piece with a clone of himself on the side opposing him is a reference to a classic cartoon gag where a character carrying something heavy would do the same thing. This gag has famously been used with Mickey Mouse and Looney Tunes characters.
This is the second time the Eds go into outer space (the first being in "A Pinch to Grow an Ed"), but the first time they go to the moon.
This episode's title, along with the horse seen on the title card, is a possible reference to the 1960's TV series Mister Ed.